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Frederick Griffith (1877–1941) was a British bacteriologist whose focus was the epidemiology and pathology of bacterial pneumonia. In January 1928 he reported what is now known as Griffith's Experiment , the first widely accepted demonstrations of bacterial transformation , whereby a bacterium distinctly changes its form and function .
Griffith's experiment discovering the "transforming principle" in Streptococcus pneumoniae (pneumococcal) bacteria. Griffith's experiment, [1] performed by Frederick Griffith and reported in 1928, [2] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.
1923: Frederick Griffith studied bacterial transformation and observed that DNA carries genes responsible for pathogenicity. [ 17 ] In Griffith's experiment , mice are injected with dead bacteria of one strain and live bacteria of another, and develop an infection of the dead strain's type. 1928: Frederick Griffith discovers that hereditary ...
Natural competence was discovered by Frederick Griffith in 1928, when he showed that a preparation of killed cells of a pathogenic bacterium contained something that could transform related non-pathogenic cells into the pathogenic type.
Streptococcus pneumoniae played a central role in demonstrating that genetic material consists of DNA. In 1928, Frederick Griffith demonstrated transformation of life turning harmless pneumococcus into a lethal form by co-inoculating the live pneumococci into a mouse along with heat-killed virulent pneumococci. [15]
Frederick Griffith published the first report of bacteria's potential for transformation in 1928. [2] Griffith observed that mice did not succumb to the "rough" type of pneumococcus (Streptococcus pneumoniae), referred to as nonvirulent, but did succumb to the "smooth" strain, which is referred to as virulent. The smooth strain's virulence ...
Horizontal gene transfer was first observed in 1928, in Frederick Griffith's experiment: showing that virulence was able to pass from virulent to non-virulent strains of Streptococcus pneumoniae, Griffith demonstrated that genetic information can be horizontally transferred between bacteria via a mechanism known as transformation. [2]
Frederick Griffith demonstrates (Griffith's experiment) that living cells can be transformed via a transforming principle, later discovered to be DNA (1928). Karl von Frisch decodes the waggle dance honey bees use to communicate the location of flowers (1940).