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  2. Tapentadol - Wikipedia

    en.wikipedia.org/wiki/Tapentadol

    It is similar to tramadol in its dual mechanism of action; namely, its ability to activate the μ-opioid receptor and inhibit the reuptake of norepinephrine. [13] Unlike tramadol, it has only weak effects on the reuptake of serotonin and is a significantly more potent opioid with no known active metabolites. [13] [15]

  3. List of drugs known for off-label use - Wikipedia

    en.wikipedia.org/wiki/List_of_drugs_known_for...

    Tramadol, an opioid painkiller, is used to treat premature ejaculation, [17] and may also be applied against restless legs syndrome. [citation needed] Low-dose naltrexone is cheap without side effects and used to treat cancer and autoimmune diseases like focal segmental glomerulosclerosis.

  4. List of side effects of tramadol - Wikipedia

    en.wikipedia.org/wiki/List_of_side_effects_of...

    The most common side effects of tramadol in order of decreasing incidence ... Note: Serious adverse effects are in bold ... Abdominal pain; Weight loss; Visual ...

  5. Tramadol - Wikipedia

    en.wikipedia.org/wiki/Tramadol

    Tramadol, sold under the brand name Ultram among others, [1] is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderately severe pain. [ 10 ] [ 14 ] When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. [ 10 ]

  6. Analgesic - Wikipedia

    en.wikipedia.org/wiki/Analgesic

    An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and ...

  7. Opioid - Wikipedia

    en.wikipedia.org/wiki/Opioid

    This requires them to increase their drug dosage to maintain the benefit, and that in turn also increases the unwanted side effects. [77] Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity to pain. [100] All of the opioids can cause side effects. [69]

  8. Dirty drug - Wikipedia

    en.wikipedia.org/wiki/Dirty_drug

    Today, pharmaceutical companies try to make new drugs as selective as possible to minimise binding to antitargets and hence reduce the occurrence of side effects and risk of adverse reactions. Examples of compounds often cited as "dirty drugs" include tramadol , chlorpromazine , olanzapine , dextromethorphan , ibogaine , and ethanol , all of ...

  9. Pentazocine - Wikipedia

    en.wikipedia.org/wiki/Pentazocine

    Pentazocine, [3] sold under the brand name Talwin among others, is a painkiller used to treat moderate to severe pain. It is believed to work by activating (agonizing) κ-opioid receptors (KOR) and μ-opioid receptors (MOR). As such it is called an opioid as it delivers its effects