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Meropenem usually results in bacterial death through blocking their ability to make a cell wall. [3] It is more resistant to breakdown by β-lactamase producing bacteria. [3] Meropenem was patented in 1983. [4] It was approved for medical use in the United States in 1996. [3] It is on the World Health Organization's List of Essential Medicines.
Carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae (CPE) are gram-negative bacteria that are resistant to the carbapenem class of antibiotics, considered the drugs of last resort for such infections. They are resistant because they produce an enzyme called a carbapenemase that disables the drug molecule.
Pseudomonas aeruginosa in Petri dish. Pseudomonas aeruginosa is a common encapsulated, Gram-negative, aerobic – facultatively anaerobic, rod-shaped bacterium that can cause disease in plants and animals, including humans. [ 1 ][ 2 ] A species of considerable medical importance, P. aeruginosa is a multidrug resistant pathogen recognized for ...
The carbapenem ertapenem is one of several first-line agents recommended by the Infectious Disease Society of America for the empiric treatment of community-acquired intra-abdominal infections of mild-to-moderate severity. Agents with anti-pseudomonal activity, including doripenem, imipenem, and meropenem, are not recommended in this population.
D11015. Meropenem/vaborbactam, sold under the brand name Vabomere among others, is a combination medication used to treat complicated urinary tract infections, complicated abdominal infections, and hospital-acquired pneumonia. [ 1 ][ 2 ][ 3 ] It contains meropenem, a beta-lactam antibiotic, and vaborbactam, a beta-lactamase inhibitor. [ 3 ]
Aztreonam. Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. [2][3] This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis. [2]
Pseudomonas is a genus of Gram-negative bacteria belonging to the family Pseudomonadaceae in the class Gammaproteobacteria. The 313 members of the genus [ 2 ][ 3 ] demonstrate a great deal of metabolic diversity and consequently are able to colonize a wide range of niches. [ 4 ]
The Entner–Doudoroff pathway (ED Pathway) is a metabolic pathway that is most notable in Gram-negative bacteria, certain Gram-positive bacteria and archaea. [1] Glucose is the substrate in the ED pathway and through a series of enzyme assisted chemical reactions it is catabolized into pyruvate. Entner and Doudoroff (1952) and MacGee and ...