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Clonidine. Clonidine, sold under the brand name Catapres among others, is an α 2A -adrenergic agonist [12] medication used to treat high blood pressure, ADHD, drug withdrawal (alcohol, opioids, or nicotine), menopausal flushing, diarrhea, spasticity, and certain pain conditions. [13]
Some treatments are controversial and are still being tested for effectiveness. Suggested treatments for chronic headaches include medication, physical therapy, acupuncture, relaxation training, and biofeedback. In addition, dietary alteration and behavioral therapy or psychological therapy are other possible treatments for chronic headaches.
Management of migraine. Migraine may be treated either prophylactically (preventive) or abortively (rescue) for acute attacks. [1] Migraine is an complex condition; there are various preventive treatments which disrupt different links in the chain of events that occur during a migraine attack. Rescue treatments also target and disrupt different ...
Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. [1] [2] [3] There are three main classes of imidazoline receptor: I 1 is involved in inhibition of the sympathetic nervous system to lower blood pressure, [4] I 2 has as yet uncertain functions but is implicated in several psychiatric conditions, [5] [6] and I 3 regulates insulin secretion.
Conolidine is an indole alkaloid. Preliminary reports suggest that it could provide analgesic effects with few of the detrimental side-effects associated with opioids such as morphine, though at present it has only been evaluated in mouse models. Conolidine was first isolated in 2004 from the bark of the Tabernaemontana divaricata (crape ...
Pheochromocytoma is a rare tumor of the adrenal medulla composed of chromaffin cells and is part of the paraganglioma (PGL) family of tumors, being defined as an intra-adrenal PGL . [ 2 ][ 4 ][ 5 ] These neuroendocrine tumors can be sympathetic, where they release catecholamines into the bloodstream which cause the most common symptoms ...
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