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The eclipse period is a variable period starting from HIV exposure in which no existing test can detect HIV. The median duration of the eclipse period in one study was 11.5 days. The window period is the time between HIV exposure and when an antibody or antigen test can detect HIV. The median window period for antibody/antigen testing is 18 days.
The window period for HIV may be up to three months, depending on the test method and other factors. RNA based HIV tests has the lowest window period. Modern and accurate testing abilities can cut this period to 25 days, 16 days, or even as low as 12 days, again, depending on the type of test and the quality of its administration and interpretation.
Viral load tests can also be used to diagnose HIV infection, especially in children under 18 months born to mothers with HIV, where the presence of maternal antibodies prevents the use of antibody-based diagnostic tests. [8] Pooled viral RNA testing shortens the window period to a median of 17 days (95% CI, 13-28 Days). [9]
The standard antibody window period begins after the last day of PEP treatment. People who received PEP are typically advised to get an antibody test at 6 months post-exposure as well as the standard 3 month test. [22] The antiretroviral regimen used in PEP is the same as the standard highly active antiretroviral therapy used to treat AIDS.
Scanning electron micrograph of HIV-1, colored green, budding from a cultured lymphocyte. HIV is the cause of the spectrum of disease known as HIV/AIDS. HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells.
HIV latency. Human Immunodeficiency Virus (HIV) has the capability to enter a latent stage of infection where it exists as a dormant provirus in CD4+ T-cells. Most latently infected cells are resting memory T cells, [ 1] however a small fraction of latently infected cells isolated from HIV patients are naive CD4 T cells. [ 2]
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