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An action potential (also known as a nerve impulse or "spike" when in a neuron) is a series of quick changes in voltage across a cell membrane. An action potential occurs when the membrane potential of a specific cell rapidly rises and falls. [1] This depolarization then causes adjacent locations to similarly depolarize.
Figure FHN: To mimick the action potential, the FitzHugh–Nagumo model and its relatives use a function g(V) with negative differential resistance (a negative slope on the I vs. V plot). For comparison, a normal resistor would have a positive slope, by Ohm's law I = GV , where the conductance G is the inverse of resistance G =1/ R .
Feedforward inputs that form synapses proximal to the soma and directly lead to action potentials; NMDA spikes generated in the more distal basal; Apical dendrites that depolarize the soma (usually insufficient to generate a somatic action potential) - Learns by growing new synapses - Inspired by the pyramidal cells in neocortex layers 2/3 and 5
The slope of phase 0 on the action potential waveform (see figure 2) represents the maximum rate of voltage change of the cardiac action potential and is known as dV/dt max. In pacemaker cells (e.g. sinoatrial node cells ), however, the increase in membrane voltage is mainly due to activation of L-type calcium channels.
Neural backpropagation is the phenomenon in which, after the action potential of a neuron creates a voltage spike down the axon (normal propagation), another impulse is generated from the soma and propagates towards the apical portions of the dendritic arbor or dendrites (from which much of the original input current originated).
Figure B. is a recording of an actual action potential N.B. Actual recordings of action potentials are often distorted compared to the schematic view because of variations in electrophysiological techniques used to make the recording. In neurophysiology, a dendritic spike refers to an action potential generated in the dendrite of a neuron ...
Rheobase is a measure of membrane potential excitability. In neuroscience, rheobase is the minimal current amplitude of infinite duration that results in the depolarization threshold of the cell membranes being reached, such as an action potential or the contraction of a muscle. [1]
Saltatory conduction. In neuroscience, nerve conduction velocity (CV) is the speed at which an electrochemical impulse propagates down a neural pathway.Conduction velocities are affected by a wide array of factors, which include age, sex, and various medical conditions.