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HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders.It is encoded by a gene of the same name belonging to the HERC family, which typically encodes large protein products with C-terminal HECT domains and one or more RCC1-like (RLD) domains.
In genetics, a locus (pl.: loci) is a specific, fixed position on a chromosome where a particular gene or genetic marker is located. [1] Each chromosome carries many genes, with each gene occupying a different position or locus; in humans, the total number of protein-coding genes in a complete haploid set of 23 chromosomes is estimated at ...
The polymorphisms may be in an OCA2 regulatory sequence, where they may influence the expression of the gene product, which in turn affects pigmentation. [13] A specific mutation within the HERC2 gene, a gene that regulates OCA2 expression, is partly responsible for blue eyes. [9] Other genes implicated in eye color variation are SLC24A4 [22 ...
The influence of menopausal symptoms on long-term Alzheimer’s risk is still being investigated, but what we do know is that, while your genetic blueprint matters, a healthy lifestyle that ...
HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. [26] [27]
A judge on Tuesday declined to immediately block Elon Musk's government efficiency department from directing firings of federal workers or accessing databases, but said the case raises questions ...
U.S. President Donald Trump's approval rating has ticked slightly lower in recent days as more Americans worried about the direction of the U.S. economy as the new leader threatens a host of ...
This means that for each MHC gene, many alleles (or gene variants) consistently exist within the population, and many individuals are heterozygous at MHC loci (meaning they possess two different alleles for a given gene locus). The vast source of genetic variation affecting an organism's fitness stems from the co-evolutionary arms race between ...