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Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. [ 1 ] Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to ...
Elixir sulfanilamide was an improperly prepared sulfonamide antibiotic that caused mass poisoning in the United States in 1937. It is believed to have killed 107 people. [ 1 ] The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act , which significantly increased ...
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The company was responsible for the elixir sulfanilamide disaster of 1937, described as one of the most consequential mass poisonings of the 20th century. [2] Elixir sulfanilamide was formulated with diethylene glycol as a solvent. The company claimed to have been unaware of the toxicity of diethylene glycol, despite the existence of published ...
Chemical structure of a generic acylsulfonamide. Acylsulfonamide is a functional group in organic chemistry that is sometimes used in medicinal chemistry. [1] It consists of a sulfonamide group (SO 2 NH) linked to an acyl group (RCO), forming the structure R 1-CO-NH-SO 2-R 2.
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria.One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist.
Jun. 16—Mayo Clinic Children's Center is again ranked as a top-performing children's hospital on U.S. News & World Report's 2021-2022 "Best Children's Hospital's rankings. Mayo Children's Center ...
Sulfamethoxazole, a sulfanilamide, is a structural analog of para-aminobenzoic acid (PABA). They compete with PABA to bind to dihydropteroate synthetase and inhibit conversion of PABA and dihydropteroate diphosphate to dihydrofolic acid, or dihydrofolate.