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High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). [1] [2] It may be referred to simply as prostatic intraepithelial neoplasia (PIN).
This recognizes that prostatic carcinomas have multiple patterns and that prognosis is more accurately determined by adding the scores of the two most prevalent patterns. Using this system, the grades of the most prevalent and second most prevalent patterns (if at least 5% of the total), are added together to yield the overall Gleason score.
However, high magnification (right image) shows the key feature of prominent nucleoli (visible at 200x magnification to make the diagnosis of "high-grade"), as well as other typical features of HGPIN. Reference for features: - Margaret Sanders, M.B.B.Ch., Murali Varma, M.B.B.S.. High grade prostatic intraepithelial neoplasia (HGPIN).
OpenEpi was developed to perform analyses found in the DOS version of Epi Info modules StatCalc and EpiTable, to improve upon the types of analyses provided by these modules, and to provide a number of tools and calculations not currently available in Epi Info. It is the first step toward an entirely web-based set of epidemiologic software tools.
A medical calculator is a type of medical computer software, whose purpose is to allow easy calculation of various scores and indices, presenting the user with a friendly interface that hides the complexity of the formulas.
A panel of epigenetic methylation marker has been explored for prognosis of ovarian cancer, and it is reported that the panel exhibited high specificity and sensitivity (both above 70%) as a screen marker. [5] Epigenetic markers have also shown promising potential as prognostic markers for bladder cancer. [6]
PDFtk (short for PDF Toolkit) is a toolkit for manipulating Portable Document Format (PDF) documents. [ 3 ] [ 4 ] It runs on Linux , Windows and macOS . [ 5 ] It comes in three versions: PDFtk Server ( open-source command-line tool ), PDFtk Free ( freeware ) and PDFtk Pro ( proprietary paid ). [ 2 ]
One theory is that CP/CPPS is a psychoneuromuscular (psychological, neurological, and muscular) disorder. [12] The theory proposes that anxiety or stress results in chronic, unconscious contraction of the pelvic floor muscles, leading to the formation of trigger points and pain. [12]