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The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na + /K +-ATPase, Na + /K + pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na + /K +-ATPase enzyme is active (i.e. it ...
The sodium–potassium pump is a critical enzyme for regulating sodium and potassium levels in cells. Potassium is the main intracellular ion for all types of cells, while having a major role in maintenance of fluid and electrolyte balance. [1] [2] Potassium is necessary for the function of all living cells and is thus present in all plant and ...
Image renamed from Image:Sodium-Potassium_pump.svg Bahasa Indonesia: Contoh transport aktif primer, di mana energi dari hidrolisis ATP langsung digabungkan dengan pergerakan zat tertentu melintasi membran yang terlepas dari spesies lainnya.
The powering force is the Na/K-ATPase on the basolateral membrane which maintains the ion concentrations inside the cells. On the luminal membrane, Na enters the cells passively; using the Na–K–Cl symporter. Then the Na/K-ATPase will pump 3 Na out into the peritubular fluid and 2 K into the cell on the non-lumen side of the cell.
An alpha subunit forms the core of the channel and is functional on its own. When the alpha subunit protein is expressed by a cell, it is able to form a pore in the cell membrane that conducts Na + in a voltage-dependent way, even if beta subunits or other known modulating proteins are not expressed. When accessory proteins assemble with α ...
In aquatic invertebrates, ionocytes perform the functions of both ion uptake and ion excretion. [2] In marine teleost fish, by expending energy to power the enzyme Na + /K + -ATPase and in coordination with other protein transporters, ionocytes pump excessive sodium and chloride ions against the concentration gradient into the ocean.
The sodium–potassium pump, a critical enzyme for regulating sodium and potassium levels in cells. Sodium ions (Na +) are necessary in small amounts for some types of plants, [1] but sodium as a nutrient is more generally needed in larger amounts [1] by animals, due to their use of it for generation of nerve impulses and for maintenance of electrolyte balance and fluid balance.
The clinical result is a rise in blood K+ level and drop of blood Na+ levels There are a wide range of possible pathological conditions that can cause sick cell syndrome, including: [citation needed] hypoxia; sepsis; hypovolaemia; malnourishment; This syndrome is well known in the field of palliative medicine as many terminal patients develop ...