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The duration of action of a drug is the length of time that particular drug is effective. [5] Duration of action is a function of several parameters including plasma half-life, the time to equilibrate between plasma and target compartments, and the off rate of the drug from its biological target. [6]
The course of a disease, also called its natural history, [3] is the development of the disease in a patient, including the sequence and speed of the stages and forms they take. [4] Typical courses of diseases include: chronic; recurrent or relapsing; subacute: somewhere between an acute and a chronic course
Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration , it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question.
It has a rapid onset (30 seconds) but very short duration of action (5–10 minutes) because of hydrolysis by various cholinesterases (such as butyrylcholinesterase in the blood). The patient will experience fasciculation due to the depolarisation of muscle neurone fibres and seconds later, flaccid paralysis will occur. [ 12 ]
Safety – Obstacles on courses are expected to be protected with nets, fences, or pads. Vertical drop – Vertical drop ranges from 450 to 1,100 metres (1,480 to 3,610 ft) for men and 450 to 800 metres (1,480 to 2,620 ft) for women. Races with two runs may be shorter. Course length – Courses require an accurate means of measurement for length.
In baseball, pace of play refers to the length of time between in-game action, specifically the length of time a pitcher takes between their pitches. A slow pace of play can extend the length of games, which is regarded as an issue in college baseball and professional baseball.
The length of the VOT in such cases is a practical measure of aspiration: The longer the VOT, the stronger the aspiration. In Navajo, for example, which is strongly aspirated, the aspiration (and therefore the VOT) lasts twice as long as it does in English: 160ms vs. 80ms for [kĘ°], and 45ms for [k]. Some languages have weaker aspiration than ...
These channels are also activated by an increase in voltage, however this time it is either due to the pacemaker potential (phase 4) or an oncoming action potential. The L-type calcium channels are activated more slowly than the sodium channels, therefore, the depolarization slope in the pacemaker action potential waveform is less steep than ...