Search results
Results From The WOW.Com Content Network
Diagram depicting a representative pan-assay interference compound. The drug-like molecule specifically interacts with target B, but the PAINS-like compound non-specifically interacts with multiple targets. Pan-assay interference compounds (PAINS) are chemical compounds that often give false positive results in high-throughput screens. [1]
It does so by acetylating the hydroxyl of a serine residue at the 530 amino acid position. [6] Normally COX produces prostaglandins, most of which are pro-inflammatory, and thromboxanes, which promote clotting. Aspirin-modified COX-2 produces 15-epi-lipoxins, which act to resolve inflammatory responses similar to other lipoxins. [7]
Iron is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically important part of many aspects of human health and disease. Hematologists have been especially interested in systemic iron metabolism, because iron is essential for red blood cells, where most of the human body's iron is contained.
It has two subdivisions, one for the detection of mechanosensory information related to touch, and the other for the nociception detection of pain and temperature. [1] The main functions of the somatosensory system are the perception of external stimuli, the perception of internal stimuli, and the regulation of body position and balance ...
Cutaneous receptors are at the ends of afferent neurons. works within the capsule. Ion channels are situated near these networks. In sensory transduction, the afferent nerves transmit through a series of synapses in the central nervous system, first in the spinal cord, the ventrobasal portion of the thalamus, and then on to the somatosensory cortex.
Hephaestin, a ferroxidase that can oxidize Fe 2+ to Fe 3+ and is found mainly in the small intestine, helps ferroportin transfer iron across the basolateral end of the intestine cells. In contrast, ferroportin is post-translationally repressed by hepcidin, a 25-amino acid peptide hormone. The body regulates iron levels by regulating each of ...
Lateral lemniscus is the first point of integration of sound and pain information. [16] Inferior colliculus (IC) aids in sound orienting to pain stimuli. [17] Superior colliculus receives IC's input, integrates visual orienting info, and uses the balance topographical map to orient the body to the pain stimuli. [18] [19]
In medicine, Carnett's sign is a finding on clinical examination in which abdominal pain remains unchanged or increases when the muscles of the abdominal wall are tensed. [1] [2] For this part of the abdominal examination, the patient can be asked to lift the head and shoulders from the examination table to tense the abdominal muscles.