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Anemia of prematurity (AOP) refers to a form of anemia affecting preterm infants [1] with decreased hematocrit. [2] AOP is a normochromic, normocytic hypoproliferative anemia. The primary mechanism of AOP is a decrease in erythropoietin (EPO), a red blood cell growth factor.
Individuals with TEC have a median age of presentation of 18–26 months; however, the disorder may occur in infants younger than 6 months and in children as old as age 10 years. Because of the gradual onset of the anemia, children are often healthier than expected from their low hemoglobin levels. [citation needed]
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Scurvy was described as early as the time of ancient Egypt, and historically it was a limiting factor in long-distance sea travel, often killing large numbers of people. [ 2 ] [ 7 ] During the Age of Sail , it was assumed that 50 percent of the sailors would die of scurvy on a major trip.
Anemia is the most common blood disorder, affecting about a fifth to a third of the global population. [1] [11] [12] [13] Iron-deficiency anemia is the most common cause of anemia worldwide, and affects nearly one billion people. [14] In 2013, anemia due to iron deficiency resulted in about 183,000 deaths – down from 213,000 deaths in 1990. [15]
Iron-deficiency anemia is anemia caused by a lack of iron. [3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [1]
Stage 3 – Anemia (reduced hemoglobin levels) is present but red blood cell appearance remains normal. [4] Stage 4 – Changes in the appearance of red blood cells are the hallmark of this stage; first microcytosis and then hypochromia develop. [4] Stage 5 – Iron deficiency begins to affect tissues, manifesting as symptoms and signs. [4]
Extreme preterm [2] is less than 28 weeks, very early preterm birth is between 28 and 32 weeks, early preterm birth occurs between 32 and 34 weeks, late preterm birth is between 34 and 36 weeks' gestation. [8] These babies are also known as premature babies or colloquially preemies (American English) [9] or premmies (Australian English). [10]