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GLP-1s (glucagon-like peptide-1 receptor agonists) are medications used to treat type 2 diabetes and obesity. You’ve probably heard of them under brand names like Ozempi c® and Wegovy ...
GLP-1 Diet Plan. GLP-1 medications — that’s glucagon-like peptide-1 receptor agonists — are prescribed alongside diet and exercise to help people lose weight or manage type 2 diabetes. But ...
Potential Risks of GLP-1 Agonists. Although GLP-1 medications can be highly effective, they are not without some risks. Due to slowed gastric emptying, common side effects may include nausea ...
Some GLP-1 agonists, such as semaglutide, are more effective than other weight loss drugs, but are still less effective than bariatric surgery in causing weight loss. [16] GLP-1 agonists' weight reduction effects come from a combination of peripheral effects as well as activity in the brain via the central nervous system . [ 17 ]
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Tirzepatide, a dual agonist of GLP-1 and GIP receptors, is approved for type 2 diabetes and obesity.With an average 20 percent weight loss at a high dosage, it appears to be more effective than GLP-1 mono agonists although there have been no head to head trials as of 2023.
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