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The first patient was treated using the Edmonton protocol in March 1999. The protocol was first published in the New England Journal of Medicine in July 2000. [1] The NEJM report was exciting for the diabetes field because the seven patients undergoing the Edmonton protocol remained insulin-independent after an average of 12 months. [citation ...
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia , tics in Tourette syndrome , mania in bipolar disorder , delirium , agitation, acute psychosis , and hallucinations from alcohol withdrawal .
Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [6] [7] [9] Its elimination half-life after multiple doses is 21 days. [10] [11] The medication is marketed in many countries throughout the world. [3] [12
There are different classes of hypoglycemic drugs, and selection of the appropriate agent depends on the nature of diabetes, age, and situation of the person, as well as other patient factors. Type 1 diabetes is a disease caused by the lack of insulin. Thus, insulin is the main treatment agent for type 1 and is typically administered via ...
Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. [1] Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion and occasionally loss of consciousness. [1]
Haloperidol, an antipsychotic medication, was a preferred agent. Furthermore, patients were illuded to believe that their torturous state was of their own making. It was used to induce intense restlessness, Parkinson's-type symptoms and overwhelming apathy which rendered the subjects unfit for public presentation in the process.
The diagnosis is suggested on patients with a history of drug exposure to the most common inducing agents such as strong antidopaminergic medications. [ 6 ] [ 40 ] The differential diagnosis includes serotonin syndrome , [ 41 ] encephalitis , toxic encephalopathy , status epilepticus , heat stroke , catatonia and malignant hyperthermia .
The glucose clamp technique was developed by University of Texas (UT) School of Medicine Professors DeFronzo, Andres and Tobin in 1979. [2] It has since been the gold standard for pharmacodynamic studies in diabetes drug development and diagnostics evaluation. [3]