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[186] [187] By the age of 50 more than 80% of American women will have contracted at least one strain of genital HPV. [185] [188] It was estimated that, in the year 2000, there were approximately 6.2 million new HPV infections among Americans aged 15–44; of these, an estimated 74% occurred to people between ages of 15 and 24. [189]
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Papillomaviridae is a family of non-enveloped DNA viruses whose members are known as papillomaviruses. [1] Several hundred species of papillomaviruses, traditionally referred to as "types", [2] have been identified infecting all carefully inspected mammals, [2] but also other vertebrates such as birds, snakes, turtles and fish.
Gardasil is an HPV vaccine for use in the prevention of certain strains of human papillomavirus (HPV). [10] [7] [8] [9] [11] It was developed by Merck & Co. [12] High-risk human papilloma virus (hr-HPV) genital infection is the most common sexually transmitted infection among women. [13]
At some point in their life, four in five people catch the sexually-transmitted virus, which is behind 99.7% of cervical-cancer cases.
Gardasil is designed to prevent infection with HPV types 16, 18, 6, and 11. HPV types 16 and 18 currently cause about 70% of cervical cancer cases, [13] [14] and also cause some vulvar, vaginal, [11] penile and anal cancers. [12] HPV types 6 and 11 are responsible for 90% of documented cases of genital warts. [17]
HPV status was the major determinant of survival, followed by smoking history and stage. 64% were HPV+ and all were in the low and intermediate-risk groups, with all non-smoking HPV+ patients in the low-risk group. 82% of the HPV+ patients were alive at three years compared to 57% of the HPV- patients, a 58% reduction in the risk of death.
When used without context, it frequently refers to infections (squamous cell papilloma) caused by human papillomavirus (HPV), such as warts. Human papillomavirus infection is a major cause of cervical cancer , vulvar cancer , vaginal cancer , penis cancer , anal cancer , and HPV-positive oropharyngeal cancers .