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Hypertrophic cardiomyopathy screening is an assessment and testing to detect hypertrophic cardiomyopathy (HCM). [ 1 ] [ 2 ] It is a way of identifying HCM in immediate relatives of family members diagnosed with HCM, and athletes as part of a sports medical . [ 3 ]
Feline hypertrophic cardiomyopathy (HCM) is the most common heart disease in domestic cats; [71] [72] [73] the disease process and genetics are believed to be similar to the disease in humans. [74] In Maine Coon cats, HCM has been confirmed as an autosomal dominant inherited trait. [75] Numerous cat breeds have HCM as a problem in the breed. [76]
The most common causes of cardiomegaly are congenital (patients are born with the condition based on a genetic inheritance), high blood pressure (which can enlarge the left ventricle causing the heart muscle to weaken over time), and coronary artery disease. In the latter case, the disease creates blockages in the heart's blood supply, leading ...
The first mutation identified in MYH6 by Niimura et al. was found in a patient population with late-onset hypertrophic cardiomyopathy. An Arg to Gln variant was found at position 795 (Arg795Gln). This mutation was located in a region of MHC-α shown to be important for binding essential light chain. [16]
Hypertrophic cardiomyopathy affects about 1 in 500 people while dilated cardiomyopathy affects 1 in 2,500. [ 3 ] [ 10 ] They resulted in 354,000 deaths up from 294,000 in 1990. [ 7 ] [ 11 ] Arrhythmogenic right ventricular dysplasia is more common in young people.
Murmurs that are due to forward flowing of blood such as aortic stenosis, and hypertrophic cardiomyopathy decrease in intensity. [ 4 ] The effect of reducing the intensity in forward flowing murmurs is much more evident in aortic stenosis rather than mitral stenosis.
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