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Propofol [7] is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia. It is chemically termed 2,6-diisopropylphenol. The formulation was approved under the brand name Diprivan. Numerous generic versions have since been released.
Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. It can lead to cardiac failure , rhabdomyolysis , metabolic acidosis , and kidney failure , and is often fatal.
A burning sensation in the mouth may be primary (i.e. burning mouth syndrome) or secondary to systemic or local factors. [1] Other sources refer to a "secondary BMS" with a similar definition, i.e. a burning sensation which is caused by local or systemic factors, [16] or "where oral burning is explained by a clinical abnormality". [17]
In 1973, while working at Imperial Chemical Industries in Alderly Park, Cheshire, England, Glen studied large series of compounds to identify those with desirable anesthetic and hypnotic properties, synthesizing propofol.
Cavalier King Charles Spaniel with bandaged foot A dog's injured leg. The health of dogs is a well studied area in veterinary medicine.. Dog health is viewed holistically; it encompasses many different aspects, including disease processes, genetics, and nutritional health, for example.
Fospropofol is metabolized in the liver by alkaline phosphatases to propofol, formaldehyde, and phosphate.The hepatic metabolism of this prodrug to an active metabolite means that peak plasma levels of propofol after the administration of a bolus of fospropofol are lower than for an equipotent dose of propofol and also that its clinical effect is more sustained.
Propofol (di-isopropyl phenol) was synthesized by Glen and colleagues in the early 1970s, [7] but its first formulations were temporarily withdrawn due to a number of adverse reactions during clinical studies. [1] In 1983, a lipid emulsion formulation of propofol was available, which carried great potential during clinical trials. [8]
Neoplasia is the most common cause of death for dogs. [69] [70] [71] Other common causes of death are heart and renal failure. [71] Their pathology is similar to that of humans, as is their response to treatment and their outcomes. Genes found in humans to be responsible for disorders are investigated in dogs as being the cause and vice versa ...