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The guidelines recommended that antidepressant treatment be considered: For people with a history of moderate or severe depression. For people with mild depression that has been present for an extended period. As a first-line treatment for moderate to severe depression.
SSRIs have dominated the market for antidepressants [1] and are recommended by the National Institute for Health and Clinical Excellence (NICE) as a first-line treatment of depression, because they tend to have fewer adverse effects than other type of antidepressants with the same effectiveness. [4]
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
It is usually reserved as a second-line treatment for depression due to a combination of its superior efficacy to the first-line treatments like fluoxetine, paroxetine and citalopram and greater frequency of side effects like nausea, headache, insomnia, drowsiness, dry mouth, constipation, sexual dysfunction, sweating and nervousness. [25] [59]
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
SSRIs are modern antidepressants often used as a first-line treatment for major depressive disorder. Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram).
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