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DNA Specimen Provenance Assignment (DSPA) also known as DNA Specimen Provenance Assay, is a molecular diagnostic test used to definitively assign biopsy specimen identity and establish specimen purity during the diagnostic testing cycle for cancer and other histopathological conditions.
Urological cancer includes renal cancer, bladder cancer, and prostate cancer. These organs are in direct contact with the urinary tract . As a result, urine samples contain cfDNA derived from apoptotic tumor cells , making ucfDNA favorable for the diagnosis of genetic and epigenetic alterations . [ 14 ]
Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.Abnormal growth of the prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels.
Researchers found that the test had a 95% sensitivity for prostate cancer of grade group 2 or greater, and 99% for grade group 3 or greater. “It does look impressive and exciting.
Prostate cancer was estimated to be the second leading cause of death by cancer in the US in 2018. [35] There are different methods used in screening for prostate cancer prostate biopsy, prostate-specific antigen testing (PSA), and digital rectal examination (DRE). In the DRE the examiner inserts a finger in the rectum of the patient and ...
How does the test work? Cancers shed DNA from dying cells into the bloodstream. Blood tests like Galleri can screen for that tumor DNA before people experience any telltale symptoms. These tests ...
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