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High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science [1] and chemistry. [ 2 ] [ 3 ] Using robotics , data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to ...
This is also known as high throughput screening (HTS) and is how most drug discoveries are made today, many cancer drugs, antibiotics, or viral antagonists have been discovered using HTS. [2] The process of HTS also tests substances for potentially harmful chemicals that could be potential human health risks. [3]
The company was a pioneer in using high throughput screening (HTS) for phenotypic drug screens. [31] The company raised over $170M in venture capital funding. [32] The HTS part of the business was sold to Wako Chemicals USA in 2010. [33] In 2007, Lustig, Chris Petersen, and Andrew Martin founded the research marketplace Assay Depot (later ...
Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds.
In high-throughput screening (HTS), one of the major goals is to select compounds (including small molecules, siRNAs, shRNA, genes, et al.) with a desired size of inhibition or activation effects. A compound with a desired size of effects in an HTS screen is called a hit. The process of selecting hits is called hit selection. [citation needed]
Such a molecule might be extracted from a natural product or even be a drug on the market which could be improved upon (so-called "me too" drugs). Other methods, such as virtual high throughput screening, [28] where screening is done using computer-generated models and attempting to "dock" virtual libraries to a target, are also often used. [21]
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