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High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science [1] and chemistry. [ 2 ] [ 3 ] Using robotics , data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to ...
Classical High throughput screening robotics are now being tied closer to cell biology, principally using technologies such as High-content screening.High throughput cell biology dictates methods that can take routine cell biology from low scale research to the speed and scale necessary to investigate complex systems, achieve high sample size, or efficiently screen through a collection.
High throughput screening of compounds and targets in drug discovery (Labeled Alpha Screen on most instruments) [12] Bead-based epitope assay [13] Cellular Uptake of nanoparticles [14] While "plate reader" usually refers to the devices described above, many variations are available. Some examples of other devices working with the microplate ...
Laboratories devoted to activities such as high-throughput screening, combinatorial chemistry, automated clinical and analytical testing, diagnostics, large-scale biorepositories, and many others, would not exist without advancements in laboratory automation. An autosampler for liquid or gaseous samples based on a microsyringe
In high-throughput screening (HTS), one of the major goals is to select compounds (including small molecules, siRNAs, shRNA, genes, et al.) with a desired size of inhibition or activation effects. A compound with a desired size of effects in an HTS screen is called a hit. The process of selecting hits is called hit selection. [citation needed]
Molecular Devices then acquired Universal Imaging Corporation in 2002, Axon Instruments in 2004, and Blueshift Technologies in 2008, broadening its portfolio to include electrophysiology products, scanners and analysis software for microarrays, and workstations for cell-based screening using high-resolution imaging.
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