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A Lindbergh perfusion pump, c. 1935, an early device for simulating natural perfusion. Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue, [1] usually referring to the delivery of blood to a capillary bed in tissue. Perfusion may also refer to fixation via perfusion, used in histological ...
Exercise. Whilst modest activity and exercise improves ventilation-perfusion matching, [19] hypoxemia may develop during intense exercise as a result of preexisting lung diseases. [20] During exercise, almost half of the hypoxemia is due to diffusion limitations (again, on average). [21] Aging. An increasingly poor match between ventilation and ...
Diffusion is the first and most important mechanism that allows the flow of small molecules across capillaries. The process depends on the difference of gradients between the interstitium and blood, with molecules moving to low concentrated spaces from high concentrated ones. [8]
Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re-+ perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).
Impaired diffusion, a reduced capacity for gas molecules to move between the air in the alveoli and the blood, which occurs when alveolar–capillary membranes thicken. This can happen in interstitial lung diseases such as pulmonary fibrosis , sarcoidosis , hypersensitivity pneumonitis , and connective tissue disorders.
2, [1] or A–a gradient), is a measure of the difference between the alveolar concentration (A) of oxygen and the arterial (a) concentration of oxygen. It is a useful parameter for narrowing the differential diagnosis of hypoxemia. [2] The A–a gradient helps to assess the integrity of the alveolar capillary unit.
If the transport of nitrogen into the vascular compartment by perfusion exceeds removal of helium by perfusion, while transfer of helium into the vascular compartment by diffusion from the perilymph and endolymph exceeds the counterdiffusion of nitrogen, this may result in a temporary increase in total gas tension, as the input of nitrogen ...
The arm–leg (blood pressure) gradient is the difference between the blood pressure measured in the arms and that measured in the legs. It is normally less than 10 mm Hg, [36] but may be increased in e.g. coarctation of the aorta. [36]