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[1] [2] It is the 6-methoxy derivative of the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT. [3] Similarly to analogues like DMT and 5-MeO-DMT, 6-MeO-DMT acts as a serotonin 5-HT 2A receptor agonist as well as a non-selective agonist of many other serotonin receptors.
Prominent reactions of metal hydroxides are their acid-base behavior. Protonation of metal hydroxides gives aquo complexes: L n M−OH + H + ⇌ L n M−OH + 2 where L n is the ligand complement on the metal M. Thus, aquo ligand is a weak acid, of comparable strength to acetic acid (pK a of about 4.8). [6] In principle but not very commonly ...
4-MeO-DMT (4-methoxy-N,N-dimethyltryptamine) is a tryptamine derivative which has some central activity in animal tests similar to that of related psychedelic tryptamine drugs, although with significantly lower potency than either 5-MeO-DMT or 4-hydroxy-DMT (psilocin).
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [1] [2] [3] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. [9]
[5] [1] [4] Like DMT, 5-MeO-DMT has a very rapid onset of action and short duration. [1] [4] However, 5-MeO-DMT is 4- to 10-fold more potent than DMT in humans. [2] 5-MeO-DMT was first synthesized in 1936 by Toshio Hoshino [9] , professor of Tokyo Institute of Technology, and was first isolated from a natural source in 1959. [5]
As with DMT, CYB004 is a potent agonist of the serotonin 5-HT 2A receptor and produces psychedelic-like effects in animals. [1] [5] [3] However, CYB004, due to its deuteration, is more resistant to metabolism than DMT and shows a longer elimination half-life (by 2.5- to 2.9-fold) and slower clearance (by 38 to 55%) in animals. [3]
C-DMT, also known as N,N-dimethyl-2-(3H-inden-1-yl)ethylamine, is a serotonin receptor agonist and a 3-indenyl ethyl amine derivative. [ 1 ] [ 2 ] [ 3 ] It is an analogue and bioisostere of the tryptamine psychedelic N , N -dimethyltryptamine (DMT) in which the indole ring has been replaced with an indene ring.
[55] [7] [13] [59] Bufotenin has about 5- to 10-fold higher affinity for the serotonin 5-HT 2A receptor than 5-MeO-DMT, about the same activational potency as 5-MeO-DMT at the receptor in vitro (EC 50 Tooltip half-maximal effective concentration = 3.49 nM and 3.87 nM, respectively), and about 3-fold higher in-vivo potency than 5-MeO-DMT when ...