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A resection margin or surgical margin is the margin of apparently non-tumorous tissue around a tumor that has been surgically removed, called "resected", in surgical oncology. The resection is an attempt to remove a cancer tumor so that no portion of the malignant growth extends past the edges or margin of the removed tumor and surrounding tissue.
Complete circumferential peripheral and deep margin assessment (CCPDMA) is the preferred method for the removal of certain cancers, especially skin cancers. [ 1 ] [ 2 ] There are two forms of CCPDMA surgery: Mohs surgery and surgical excision coupled with margin assessment.
In recognition of his contribution, the depth of invasion of melanoma is referred to by the eponym Breslow's depth. Subsequent studies confirmed and refined the role of depth of invasion in the prognosis of malignant melanoma. [2] [3] Currently, Breslow's depth is included in the AJCC staging guidelines for melanoma as a major prognostic factor.
Mohs surgery is the gold standard method for obtaining complete margin control during removal of a skin cancer (complete circumferential peripheral and deep margin assessment - CCPDMA) using frozen section histology. [1] CCPDMA or Mohs surgery allows for the removal of a skin cancer with very narrow surgical margin and a high cure rate.
Many surgeons consider 0.5 cm (0.2 in) the standard of care for standard excision of melanoma-in-situ, [106] but 0.2 cm (0.1 in) margin might be acceptable for margin controlled surgery (Mohs surgery, or the double-bladed technique with margin control). The wide excision aims to reduce the rate of tumor recurrence at the site of the original ...
Skin cancer is the uncontrolled proliferation of abnormal skin cells, usually developing on skin exposed to ultraviolet radiation. Squamous cell carcinoma , basal cell carcinoma , and melanoma are the three main types of skin cancer, [ 5 ] with the former two being non-melanoma skin cancer.
In histopathology, radicality of tumor excisions is generally defined as the absence of tumor cells in a certain resection margin, with the specific margin width varying by tumor type and local guidelines. [3] A non-radical excision may require re-excision. [clarification needed]
This is the ideal method of diagnosis of small melanomas (when performed as an excision). Ideally, an entire melanoma should be submitted for diagnosis if it can be done safely and cosmetically. This excisional biopsy is often done with a narrow surgical margin to make sure the deepest thickness of the melanoma is given before prognosis is decided.