Search results
Results From The WOW.Com Content Network
A resection margin or surgical margin is the margin of apparently non-tumorous tissue around a tumor that has been surgically removed, called "resected", in surgical oncology. The resection is an attempt to remove a cancer tumor so that no portion of the malignant growth extends past the edges or margin of the removed tumor and surrounding tissue.
Complete circumferential peripheral and deep margin assessment (CCPDMA) is the preferred method for the removal of certain cancers, especially skin cancers. [ 1 ] [ 2 ] There are two forms of CCPDMA surgery: Mohs surgery and surgical excision coupled with margin assessment.
Mohs surgery is the gold standard method for obtaining complete margin control during removal of a skin cancer (complete circumferential peripheral and deep margin assessment - CCPDMA) using frozen section histology. [1] CCPDMA or Mohs surgery allows for the removal of a skin cancer with very narrow surgical margin and a high cure rate.
In recognition of his contribution, the depth of invasion of melanoma is referred to by the eponym Breslow's depth. Subsequent studies confirmed and refined the role of depth of invasion in the prognosis of malignant melanoma. [2] [3] Currently, Breslow's depth is included in the AJCC staging guidelines for melanoma as a major prognostic factor.
Surgical excision with a large safety margin is the main treatment for localized amelanotic melanoma. The suggested margin size for amelanotic melanoma is debatable since it varies according to the lesion's development, thickness, and invasion depth. [34] Guidelines from the Annals of Surgery, however, suggest that melanomas larger than 2 mm be ...
Malignant melanoma of the skin. This is as it would appear on the patient. Malignant melanoma of the skin. This is a section of tissue, stained with hematoxylin & eosin, and viewed on a microscope slide. Surgical pathology is the most significant and time-consuming area of practice for most anatomical pathologists.
Pictogram of margin controlled histology or CCPDMA Pictogram of standard bread loafing histology False negative in standard bread loafing histology. Bread loafing is a common method of processing surgical specimens for histopathology. The process involves cutting the specimen into 3 or more sections. [1]
In histopathology, radicality of tumor excisions is generally defined as the absence of tumor cells in a certain resection margin, with the specific margin width varying by tumor type and local guidelines. [3] A non-radical excision may require re-excision. [clarification needed]