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Tacrolimus 0.1% Ointment As an ointment , tacrolimus is used in the treatment of dermatitis (eczema), in particular atopic dermatitis , if topical corticosteroids and moisturisers fail in helping. [ 17 ] [ 18 ] It suppresses inflammation in a similar way to steroids , and is equally as effective as a mid-potency steroid.
Pimecrolimus has a similar mode of action to that of tacrolimus but is more selective, with no effect on dendritic (Langerhans) cells. [19] It has lower permeation through the skin than topical steroids or topical tacrolimus [20] although they have not been compared with each other for their permeation ability through mucosa. In addition, in ...
Aquaphor is offered in four product ranges. There are two skin protectant ointments: [1] Aquaphor Original Ointment, used as a compounding agent; [2] [3] and Aquaphor Advanced Therapy Healing Ointment, sold in mass retail outlets. The other product ranges include: Aquaphor Lip Repair; Lip Repair + Protect SPF 30; and Aquaphor Baby.
Although it is a structural analogue of tacrolimus, it acts somewhat differently and has different side-effects. Contrary to ciclosporin and tacrolimus, drugs that affect the first phase of T lymphocyte activation, sirolimus affects the second phase, namely signal transduction and lymphocyte clonal proliferation.
Weaker topical steroids are utilized for thin-skinned and sensitive areas, especially areas under occlusion, such as the armpit, groin, buttock crease, and breast folds.. Weaker steroids are used on the face, eyelids, diaper area, perianal skin, and intertrigo of the groin or body fo
It is used as a cream or ointment applied to the skin. [6] Common side effects include itchiness and rash at the site of application, headache, and nausea. [6] Long term use may result in increased growth of fungi. [6] Use during pregnancy and breastfeeding appears to be safe. [6] Mupirocin is chemically a carboxylic acid. [8]
Common side effects include skin irritation, dry skin, redness, pimples, and telangiectasia. [8] Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome. [8] Use in pregnancy and breastfeeding is of unclear safety. [12] Clobetasol is believed to work by activating steroid receptors. [8]
Germolene's active ingredients include phenol 1.2% (providing antiseptic, locally analgesic and antipruritic effects) and chlorhexidine digluconate 0.25%. The Germoloids line of Germolene products, intended for use on haemorrhoids , also includes zinc oxide , and the analgesic lidocaine hydrochloride .