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Extremely advanced TB: 40 to 60 mg daily tapered off over 4 to 8 weeks TB in children: 2 to 5 mg/kg/day for one week, 1 mg/kg/day the next week, then tapered off over 5 weeks Steroids may be of benefit in peritonitis , miliary disease , tubercular osteomyelitis, TB osteomyelitis, laryngeal TB, lymphadenitis, and genitourinary disease, but the ...
In a recently published metaanalysis, [26] with data from both developed and developing countries, QuantiFERON-TB Gold In Tube had a pooled sensitivity for active TB of 81% and specificity of 99.2%, whereas T-SPOT.TB had a pooled sensitivity of 87.5% and specificity of 86.3%. In head-to-head comparisons, the sensitivity of IGRAs surpassed TST.
If TB bacteria gain entry to the blood stream from an area of damaged tissue, they can spread throughout the body and set up many foci of infection, all appearing as tiny, white tubercles in the tissues. [96] This severe form of TB disease, most common in young children and those with HIV, is called miliary tuberculosis. [97]
Children less than four years of age, or children and adolescents exposed to adults in high-risk categories; 15 mm or more is positive in Persons with no known risk factors for TB [13] A tuberculin test conversion is defined as an increase of 10 mm or more within a two-year period, regardless of age.
The gun injected PPD equivalent to 100,000 units per ml to the skin over the flexor surface of the left forearm in a circular pattern of six. The test was read between two and seven days later. The injection could not be into sites containing superficial veins. The reading of the Heaf test was defined by a scale: [6]
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The Tygerberg score is a clinical decision tool that allows the clinician to decide whether pericarditis is due to tuberculosis or not. It uses five variables: Weight loss (1 point) Night sweats (1 point) Fever (2 points) Serum globulin >40 g/L (3 points) Blood leukocyte count <10 × 10 9 /l (3 points)
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