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It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. [2] [3] Typically, it becomes an option once a person is doing well on the individual components. [4] It is taken by mouth. [3] Common side effects include dizziness, headache, cough, and feeling tired. [2] Severe side effects may include angioedema and low blood ...
Lisinopril is taken orally (swallowed by mouth). [7] Full effect may take up to four weeks to occur. [7] Common side effects include headache, dizziness, feeling tired, cough, nausea, and rash. [7] Serious side effects may include low blood pressure, liver problems, hyperkalemia (high blood potassium), and angioedema. [7]
Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide. Quinapril /hydrochlorothiazide (trade name Accuretic) [ 2 ] Lisinopril/hydrochlorothiazide is marketed as Prinzide, [ 3 ] Zestoretic, [ 4 ] and many others.
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. [1] [2] This class of medicine works by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
A case study of two brothers with the condition, two years of treatment with hydrochlorothiazide reduced the incidence of kidney stones and improved kidney function. [22] The thiazide-like diuretic chlortalidone reduced urine calcium oxalate in seven of the eight males with inactivated CLCN5 gene that participated in the study. [ 23 ]
[2] [3] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost. [2] [3] The combination was approved for medical use in the United States in 1965. [5] In 2022, it was the 116th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [6] [7]