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Figure 1. Early Symptoms of HIV. The stages of HIV infection are acute infection (also known as primary infection), latency, and AIDS.Acute infection lasts for several weeks and may include symptoms such as fever, swollen lymph nodes, inflammation of the throat, rash, muscle pain, malaise, and mouth and esophageal sores.
As globus sensation is a symptom, a diagnosis of globus pharyngis is typically a diagnosis of exclusion.If globus sensation is presenting with other symptoms such as pain, swallowing disorders such as aspiration or regurgitation (dysphagia), weight loss, or voice change, [10] an organic cause needs to be investigated, typically with endoscopy.
This swelling may be on one side or both sides, may cause disfigurement and may be painful. [2] Xerostomia (dry mouth) with no other cause such as a side effect of medications. [2] HIV-SGD may be the presenting sign of HIV infection. [3] There may also be xerophthalmia (dry eyes) and arthralgia (joint pain), similar to Sjögren syndrome. [3]
Due to lymphoproliferation in the intraglandular lymphoid tissue, obstruction within the epithelium results in cystic expansion, which is the cause of cystic parotid lesions found in PGL. [2] This condition frequently occurs in people in the latency period of HIV/AIDS. [1] The lymphatic system is part of the immune surveillance system.
They cause muscle tension on the cricoid cartilage, leading to a globus feeling. Pharyngeal spasms, a more common source of a globus feeling, cause tension on the thyroid cartilage. They move up and down, left and right in the pharyngeal muscles. Both may be present. The patient complains about the signs and symptoms enumerated above.
Based on symptoms, confirmation of HIV infection (serology), confirmation of organ infiltration by CD8+ T cells (tissue biopsy), and exclusion of other autoimmune conditions Differential diagnosis Primary Sjogren's Syndrome, IgG4-related disease, chronic hepatitis C infection, chronic HTLV1 infection, chronic graft versus host disease, and ...
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