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The isoelectric point (pI, pH(I), IEP), is the pH at which a molecule carries no net electrical charge or is electrically neutral in the statistical mean. The standard nomenclature to represent the isoelectric point is pH(I). [1] However, pI is also used. [2] For brevity, this article uses pI.
Amino acids have zero mobility in electrophoresis at their isoelectric point, although this behaviour is more usually exploited for peptides and proteins than single amino acids. Zwitterions have minimum solubility at their isoelectric point, and some amino acids (in particular, with nonpolar side chains) can be isolated by precipitation from ...
The isoelectric point is at approximately a pH of 8. [17] [6] There are no internal repeats in the amino acid sequence of TMEM212. [18] [19] In addition, all amino acids are in normal abundance. [18] Human TMEM212 displays a similar molecular weight and isoelectric point to its orthologs as displayed in Table 1. TMEM212 Protein Topology.
Transmembrane protein 238 is composed of 176 amino acids, weighing approximately 18.0 kDa. [6] It has a basal isoelectric point of approximately 11.5. [11] The protein is rich in alanine, arginine, and small amino acids, with a greater preponderance of basic amino acids.
The gene has 8 exons and locates at chromosome band 14q13. The human protein proteasome subunit alpha type-6 is also known as 20S proteasome subunit alpha-1 (based on systematic nomenclature). The protein is 27 kDa in size and composed of 246 amino acids. The calculated theoretical pI (isoelectric point) of this protein is 6.35.
Protein isoform X1 is 1179 amino acids long, has a molecular weight of 136.4 kilodaltons (kDa) and an isoelectric point (pI) of 8.1. [ 6 ] [ 7 ] KIAA1257 contains a domain of unknown function ( DUF ) 4550 in the first third of the protein sequence that has a high lysine content (15%). [ 6 ]
In approximately neutral aqueous solution (pH ≅ 7), the basic amino group is mostly protonated and the carboxylic acid is mostly deprotonated, so that the predominant species is the zwitterion H 3 N + −RCH−COO −. The pH at which the average charge is zero is known as the molecule's isoelectric point.
The mature Homo sapiens homolog of the CEFIP protein encoded by C10orf71 is 1435 amino acids (aa) in length and weighs approximately 156.5 kDa. [6] This homolog has an isoelectric point of 5.94. [ 6 ]