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  2. Progressive multifocal leukoencephalopathy - Wikipedia

    en.wikipedia.org/wiki/Progressive_multifocal...

    Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). It is caused by the JC virus, which is normally present and kept under control by the immune system. The ...

  3. Acute promyelocytic leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_promyelocytic_leukemia

    Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]

  4. Promyelocytic leukemia protein - Wikipedia

    en.wikipedia.org/wiki/Promyelocytic_leukemia_protein

    Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [ 5 ] of the cell nucleus.

  5. Cleveland Clinic Lou Ruvo Center for Brain Health - Wikipedia

    en.wikipedia.org/wiki/Cleveland_Clinic_Lou_Ruvo...

    The ceremonial groundbreaking of the Lou Ruvo Center for Brain Health occurred on February 9, 2007. Dignitaries who attended the groundbreaking ceremonies for the $70 million project included founder Larry Ruvo, Frank Gehry, U.S. Senator Harry Reid and John Ensign; U.S. Representative Shelley Berkley, Jon Porter and Dean Heller, Gov. Jim Gibbons, Mayor Oscar Goodman, former Gov. Kenny Guinn ...

  6. Genomic Medicine Institute - Wikipedia

    en.wikipedia.org/wiki/Genomic_Medicine_Institute

    The Genomic Medicine Institute [1] at the Cleveland Clinic is an inter-disciplinary institute and department that focuses on patient care, patient-oriented research, and outreach and education in personalized healthcare guided by genetics and genomics.

  7. Cleveland Clinic - Wikipedia

    en.wikipedia.org/wiki/Cleveland_Clinic

    Cleveland Clinic Children's (CCC) is a pediatric acute care children's teaching hospital located in Cleveland, Ohio on the main campus of Cleveland Clinic. The hospital has 389 pediatric beds [ 87 ] and is affiliated with Cleveland Clinic Lerner College of Medicine , [ 13 ] Case Western Reserve University School of Medicine , Heritage College ...

  8. Human polyomavirus 2 - Wikipedia

    en.wikipedia.org/wiki/Human_polyomavirus_2

    The boxed warning was added on February 19, 2009, for the drug efalizumab (Raptiva) includes a statement that Human polyomavirus 2, resulting in progressive multifocal leukoencephalopathy, developed in three patients who received efalizumab in clinical trials. The drug was pulled off the U.S. market because of the association with PML on April ...

  9. Medical guideline - Wikipedia

    en.wikipedia.org/wiki/Medical_guideline

    Plates vi & vii of the Edwin Smith Papyrus (around the 17th century BC), among the earliest medical guidelines. A medical guideline (also called a clinical guideline, standard treatment guideline, or clinical practice guideline) is a document with the aim of guiding decisions and criteria regarding diagnosis, management, and treatment in specific areas of healthcare.

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