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Jaundice. Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels. [3][6] Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. [7]
Frequency. 1 in 3,000–4,000 people. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [1][2][3] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis.
Genetic liver disease: A genetic disorder, known as alagille syndrome, which presents by the age of two, can affect the liver, the heart, and other parts of the body. The symptoms of any of these ...
Hyperbilirubinemia in adults. Hyperbilirubinemia is a clinical condition describing an elevation of blood bilirubin level due to the inability to properly metabolise or excrete bilirubin, a product of erythrocytes breakdown. In severe cases, it is manifested as jaundice, the yellowing of tissues like skin and the sclera when excess bilirubin ...
The disease has an incidence is 0.4–2.0 cases/100,000 and a prevalence of 16.2 cases/100,000, making it a rare disease. [42] [40] Nonetheless, PSC accounts for 6% of liver transplants in the US due to its eventual progression to end-stage liver disease, with a mean transplant-free survival of 21.3 year. [40]
Cirrhosis. Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is a condition of the liver in which the normal functioning tissue, or parenchyma, is replaced with scar tissue (fibrosis) and regenerative nodules as a result of chronic liver disease. [6][7][8] Damage to the liver leads to repair of liver ...
Oily stool, a.k.a. steatorrhea. Steatorrhea refers to bulky, foul-smelling, oily stool that tends to be pale in color and float in the toilet bowl, resisting flushing. (These are the 9 most common ...
Its most definitive treatment is a liver transplant, [1] but disease recurrence can occur in 25-30% of cases. [6] PSC is a rare disease and most commonly affects people with IBD. [2] About 3.0 to 7.5% of people with ulcerative colitis have PSC, and 80% of people with PSC have some form of IBD. [3] Diagnosis usually occurs in people in their 30s ...