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Spindle-cell hemangioendothelioma [3]) is a vascular tumor that was first described in 1986 by Sharon Weiss, M.D., [4] and commonly presents in a child or young adult who develops blue nodules of firm consistency on a distal extremity.
A vascular tumor is a vascular anomaly where a tumor forms from cells that make blood or lymph vessels; a soft tissue growth that can be either benign or malignant. [1] Examples of vascular tumors include hemangiomas, hemangioendotheliomas, Kaposi's sarcomas, angiosarcomas, and hemangioblastomas. An angioma refers to any type of benign vascular ...
A hemangioma or haemangioma is a usually benign vascular tumor derived from blood vessel cell types. The most common form, seen in infants, is an infantile hemangioma, known colloquially as a "strawberry mark", most commonly presenting on the skin at birth or in the first weeks of life. A hemangioma can occur anywhere on the body, but most ...
Hemangiopericytomas are tumors that are derived from specialized spindle shaped cells called pericytes, which line capillaries. [4] Hemangiopericytoma is an aggressive mesenchymally derived tumor with oval nuclei with scant cytoplasm. There is dense intercellular reticulin staining. Tumor cells can be fibroblastic, myxoid, or pericytic. These ...
Differential diagnosis includes vascular malformation, angioma, pyogenic granuloma, angiosarcoma, epithelioid hemangioendothelioma, Kaposi’s sarcoma, and other more rare vascular tumors. Three forms of intravascular papillary endothelial hyperplasia exist: the primary or pure form, the secondary or mixed form, and the extravascular form.
Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that is locally aggressive but without metastatic potential. It occurs particularly in the skin, deep soft tissue, retroperitoneum, mediastinum, and rarely in bone. Although lesions occur solitary, they often involve large areas of the body, such as the head/neck region (40% ...
Pericytes envelop the endothelial cells, [9] which can exhibit a combination of plump and flat cells without pleomorphism or mitotic patterns. [ 10 ] Immunohistochemically , an microvenular hemangioma's endothelial cells show positive staining for CD31 , CD34 , and factor VIII , while its pericytes show positive staining for SMA.
Angiomas are benign tumors derived from cells of the vascular or lymphatic vessel walls (endothelium) or derived from cells of the tissues surrounding these vessels. [1] [2] Angiomas are a frequent occurrence as patients age, but they might be an indicator of systemic problems such as liver disease. They are not commonly associated with cancer.