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The main metabolite excreted in the urine is 11-Nor-9-carboxy-THC, also known as THC-COOH. Most cannabis drug tests yield a positive result when the concentration of THC-COOH in urine exceeds 50 ng/mL. [10] Urine testing is an immunoassay based test on the principle of competitive binding. Drugs which may be present in the urine specimen ...
In 2015, the first government standards for testing were proposed in Colorado's legislature, when potency and microbial testing became mandatory in the state. [11] [12] [13] Colorado cannabis testing laboratories, such as AgriScience Labs, are regulated by the Colorado Department of Revenue's Marijuana Enforcement Division and the Colorado Department of Public Health and Environment. [14]
The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time. Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and ...
The tetrad test is a series of behavioral paradigms in which rodents treated with cannabinoids such as THC show effects. [1] [2] It is widely used for screening drugs that induce cannabinoid receptor-mediated effects in rodents. The four behavioral components of the tetrad are spontaneous activity, catalepsy, hypothermia, and analgesia.
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Despite the CBD and THC having the same molecular weight, multiple analytical methods are able to differentiate them. [11] "on the recovery of both THC (86.7−90.0%) and CBD (92.3−95.6%). The slightly lower recovery of THC can be explained by the fact that THC is less polar than CBD and more likely to remain in the nonpolar sunflower oil." [11]
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