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Tumoral entities include leiomyosarcomas, endometrial stromal sarcomas, carcinosarcomas and "other" sarcomas. [3] [1] If the lesion originates from the stroma of the uterine lining it is an endometrial stromal sarcoma; If the uterine muscle cell is the originator the tumor is a uterine leiomyosarcoma.
Uterine serous carcinoma is a malignant form of serous tumor that originates in the uterus. It is an uncommon form of endometrial cancer that typically arises in postmenopausal women. It is typically diagnosed on endometrial biopsy , prompted by post-menopausal bleeding .
Uterine sarcoma: vaginal bleeding, mass in the vagina [2] Types: Endometrial cancer, uterine sarcoma [3] Risk factors: Endometrial cancer: obesity, metabolic syndrome, type 2 diabetes, tamoxifen use, unopposed estrogens, late menopause, family history of the condition [1] Uterine sarcoma: radiation therapy to the pelvis [2] Treatment
Carcinosarcoma of the uterus. In gross appearance, MMMTs are fleshier than adenocarcinomas, may be bulky and polypoid, and sometimes protrude through the cervical os.On histology, the tumors consist of adenocarcinoma (endometrioid, serous or clear cell) mixed with the malignant mesenchymal elements; alternatively, the tumor may contain two distinct and separate epithelial and mesenchymal ...
Endometrial cancer is sometimes called "uterine cancer", although it is distinct from other forms of cancer of the uterus such as cervical cancer, uterine sarcoma, and trophoblastic disease. [9] The most frequent type of endometrial cancer is endometrioid carcinoma, which accounts for more than 80% of cases. [3]
C and D. Immunohistochemistry of p53 shows that high-grade serous carcinoma cells are diffusely positive for p53, a pattern consistent with a missense TP53 mutation while the adjacent epithelial cells from the background serous borderline tumor are only focally and weakly positive, a pattern consistent with a wild-type TP53 sequence.