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DNA damage is the main indication for a cell to "restrict" and not enter the cell cycle. The decision to commit to a new round of cell division occurs when the cell activates cyclin-CDK-dependent transcription which promotes entry into S phase. This check point ensures the further process. [10]
Transformation occurs and is accelerated when maintenance of genomic integrity breaks down especially at the gross level of whole chromosomes or large portions of them. In fact, aneuploidy is the most common characteristic of human solid tumors and thus the spindle assembly checkpoint might be regarded as a possible target for anti-tumour ...
Later work confirmed the circular permutation between the pair [2] and showed that concanavalin A is permuted post-translationally [3] through cleavage and an unusual protein ligation. [ 4 ] After the discovery of a natural circularly permuted protein, researchers looked for a way to emulate this process.
Protein structures range in size from tens to several thousand amino acids. [2] By physical size, proteins are classified as nanoparticles, between 1–100 nm. Very large protein complexes can be formed from protein subunits. For example, many thousands of actin molecules assemble into a microfilament.
Ribbon diagrams, also known as Richardson diagrams, are 3D schematic representations of protein structure and are one of the most common methods of protein depiction used today. The ribbon depicts the general course and organisation of the protein backbone in 3D and serves as a visual framework for hanging details of the entire atomic structure ...
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The two-round system (TRS or 2RS), also called ballotage, top-two runoff, or two-round plurality (as originally termed in French [1]), is a single winner voting method. It is sometimes called plurality-runoff , [ 2 ] although this term can also be used for other, closely-related systems such as instant-runoff (or ranked-choice) voting or the ...
The principle of tandem-affinity purification of multiprotein complexes is not limited to the combination of CBP and Protein A tags used in the original work by Rigaut et al. (1999). For example, the combination of FLAG- and HA-tags has been used since 2000 by the group of Nakatani [ 10 ] [ 11 ] to purify numerous protein complexes from ...