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The absence of fructokinase results in the inability to phosphorylate fructose to fructose-1-phosphate within the cell. As a result, fructose is neither trapped within the cell nor directed toward its metabolism. [11] Free fructose concentrations in the liver increase and fructose is free to leave the cell and enter plasma.
[35] [58] Furthermore, high fructose consumption promotes fat accumulation in the liver by stimulating de novo lipogenesis in the liver and reducing the beta-oxidation of fat. [20] Unlike the sugar glucose, the enzyme fructokinase rapidly metabolizes fructose. This leads to a decreased level of intracellular adenosine triphosphate (ATP). [20]
In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. [1] Lipogenesis encompasses both fatty acid and triglyceride synthesis , with the latter being the process by which fatty acids are esterified to glycerol before ...
The reduction of adipose tissue de novo lipogenesis, and the increase in liver de novo lipogenesis due to obesity and insulin resistance leads to fatty liver disease. Fructose consumption (in contrast to glucose) activates both SREBP-1c and ChREBP in an insulin independent manner. [8] Although glucose can be converted into glycogen in the liver ...
In animals, these fats are obtained from food and are synthesized by the liver. [1] Lipogenesis is the process of synthesizing these fats. [2] [3] The majority of lipids found in the human body from ingesting food are triglycerides and cholesterol. [4] Other types of lipids found in the body are fatty acids and membrane lipids.
An example of a coupled reaction is the phosphorylation of fructose-6-phosphate to form the intermediate fructose-1,6-bisphosphate by the enzyme phosphofructokinase accompanied by the hydrolysis of ATP in the pathway of glycolysis. The resulting chemical reaction within the metabolic pathway is highly thermodynamically favorable and, as a ...
Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate. ATP + {\displaystyle \longrightarrow } ADP + ATP + D-fructose → ADP + D-fructose-1-phosphate [ 1 ]
12914 Ensembl ENSG00000005339 ENSMUSG00000022521 UniProt Q92793 P45481 RefSeq (mRNA) NM_001079846 NM_004380 NM_001025432 RefSeq (protein) NP_001073315 NP_004371 n/a Location (UCSC) Chr 16: 3.73 – 3.88 Mb Chr 16: 3.9 – 4.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding ...