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Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. [4] Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, love, reproduction, childbirth, and the period after childbirth.
The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. [4] [5] In humans, the oxytocin receptor is encoded by the OXTR gene [6] [7] which has been localized to human chromosome 3p25. [8] Evolutionary tree of the oxytocin, vasotocin, mesotocin and isotocin receptors and ...
A biological basis for this regulation appears to be oxytocin. [3] Oxytocin has been tied to a broad array of social relationships and activities, including peer bonding, sexual activity, and affiliative preferences. [3] Oxytocin is released in humans in response to a broad array of stressors, especially those that may trigger affiliative needs.
A neurohormone is any hormone produced and released by neuroendocrine cells (also called neurosecretory cells) into the blood. [1] [2] By definition of being hormones, they are secreted into the circulation for systemic effect, but they can also have a role of neurotransmitter or other roles such as autocrine (self) or paracrine (local) messenger.
Through research, Sylvia Scribner sought to understand and create a decent life for all people regardless of geographical position, race, gender, and social class. [2] Using anthropological field research and psychological experimentation, Scribner tried to dig deeper into human mental functioning and its creation through social practice in different societal and cultural settings.
Synthetic oxytocin, sold under the brand name Pitocin among others, is a medication made from the peptide oxytocin. [6] [7] As a medication, it is used to cause contraction of the uterus to start labor, increase the speed of labor, and to stop bleeding following delivery. [6]
Oxytocin, an example of an oxytocin receptor agonist.. An oxytocin receptor agonist is a compound that acts as an agonist of the oxytocin receptor. [1] [2] Examples include peptide oxytocin receptor agonists like oxytocin (Pitocin, Syntocinon), carbetocin (Duratocin, Pabal), and demoxytocin (Sandopart) and small-molecule oxytocin receptor agonists like TC OT 39, WAY-267464, and LIT-001.
[1] [2] [3] It was the first small-molecule oxytocin receptor agonist to be shown to reduce social dysfunction in animals. [1] [2] LIT-001 shows blood–brain barrier permeability and has a relatively long elimination half-life in rodents, giving it an advantageous drug profile relative to peptide oxytocin receptor agonists like oxytocin.