Search results
Results From The WOW.Com Content Network
Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene. It is characterized by lower than average IQ (typically about 85), problematic impulsive behavior (such as pyromania, hypersexuality and violence), sleep disorders and mood swings. [1] [2] It was identified in fourteen males from one family in 1993.
A dysfunctional MAOA gene has been correlated with increased aggression levels in mice, [60] [61] and has been correlated with heightened levels of aggression in humans. [62] In mice, a dysfunctional MAOA gene is created through insertional mutagenesis (called 'Tg8'). [60] Tg8 is a transgenic mouse strain that lacks functional MAO-A enzymatic ...
The human genetics related to aggression have been studied and the main genes have been identified. The DAT1 and DRD2 genes are heavily related to the genetics of aggression. [17] [18] The DAT1 gene plays a role for its heavy relation to regulation of neurotransmission. The DRD2 Gene results in humans finding seemingly rewarding paths such as ...
A functional polymorphism in the monoamine oxidase A (MAOA) gene promoter can moderate the association between early life trauma and increased risk for violence and antisocial behavior. Low MAOA activity is a significant risk factor for aggressive and antisocial behavior in adults who report victimization as children. Persons who were abused as ...
A variant of the gene that encodes the neurotransmitter metabolizing enzyme monoamine oxidase-A (MAOA), which relates to neural systems involved in aggression, plays a key role in regulating behavior following threatening events. Brain imaging studies show patterns of arousal in areas of the brain that are associated with aggression in response ...
The MAOA gene reduces the production of MAOA, leading to increased incidents of impulsive aggression. A 26-year study in New Zealand found strong correlation between experience of childhood abuse and criminal or violent behavior in males with the MAOA gene. [9] In that study, impulsive aggression was found to be nine times more likely to ...
It can also be energetically costly, and extreme or out of context aggression can be disadvantageous or deleterious, especially in social organisms. [30] Aggression is a complex trait that is regulated by many interacting genes and gene expression is highly variable depending on environment (phenotypic plasticity).
A possible link between predisposition to novelty seeking and a genotype of the MAO-A gene has been found. [58] A particular variant (or genotype), dubbed "warrior gene" in the popular press, was over-represented in Māori. This supported earlier studies finding different proportions of variants in different ethnic groups.