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Serious side effects may include angioedema, gallstones, liver problems, and muscle breakdown. [3] Use in pregnancy and breastfeeding is of unclear safety. [5] It belongs to the fibrates group of medications and works by decreasing the breakdown of lipids in fat cells. [3] Gemfibrozil was patented in 1968, and came into medical use in 1982. [6]
Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). Fibrates decrease the synthesis of bile acid by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression, therefore making it easier for cholesterol to precipitate and increasing the risk for gallstones.
Fenofibrate (sold under the brand name Tricor among others), is an oral medication of the fibrate class used to treat abnormal blood lipid levels. [3] It is less commonly used compared to statins because it treats a different type of cholesterol abnormality to statins.
Related: Benadryl for Dogs: Side Effects of Long-Term Use. Signs of Benadryl Overdose in Dogs. At normal doses, Benadryl is quite safe, but a survey of over 600 dogs (1) found the following signs ...
Side-effects, drug interactions, and allergenic sensitivities are concerns when administering any medication to a person's dog. The Canine Liver Disease Foundation claims that many common drugs also can lead to liver damage in dogs, although they do not specifically cite any of the abovementioned drugs prescribed for dog anxiety.
Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
Idiopathic head tremors are characterized by three movements: rotational, up and down, and side to side. They occur spontaneously and typically last for 1–3 minutes. [3] There is often not a postictal stage that generally follows a seizure, because idiopathic head tremors are not considered seizure activity. Dogs are generally alert and ...
Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [12] [16] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...