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Prostacyclin (also called prostaglandin I 2 or PGI 2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator. When used as a drug, it is also known as epoprostenol. [1] The terms are sometimes used interchangeably. [2]
The prostacyclin receptor, also termed the prostaglandin I 2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors.IP binds to and mediates the biological actions of prostacyclin (also termed prostaglandin I 2, PGI 2, or when used as a drug, epoprostenol).
The following is a comparison of different types of prostaglandin, including prostaglandin I 2 (prostacyclin; PGI 2), prostaglandin D 2 (PGD 2), prostaglandin E 2 (PGE 2), and prostaglandin F 2α (PGF 2α). [19]
19223 Ensembl ENSG00000124212 n/a UniProt Q16647 O35074 RefSeq (mRNA) NM_000961 NM_008968 RefSeq (protein) NP_000952 NP_032994 Location (UCSC) Chr 20: 49.5 – 49.57 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in ...
All other prostanoids originate from PGH (as PGH 1, PGH 2, or PGH 3). The image at right shows how PGH 2 (derived from Arachidonic acid) is converted: By PGE synthetase into PGE2 (which in turn is converted into PGF2) By PGD synthetase into PGD2; By Prostacyclin synthase into prostacyclin (PGI2) By Thromboxane synthase into thromboxanes TXA
Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, (i.e. PGD2), PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2. [1]
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