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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
In the UK in 2015, there were 3.33 million procedures on rodents (80% of total procedures that year). The most common species used were mice (3.03 million procedures, or 73% of the total) and rats (268,522, or 6.5%).
[6] [2] [4] Existing resistant strains of mice, such as C57BL/6, C57BL/10 and AKR, may not have clinical signs that viruses can cause for other animals. [7] It is important to note that the genetic background of the mouse can affect the infection, which means that host factors are involved in the regulation of susceptibility and resistance to ...
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
While Calhoun was working at the National Institute of Mental Health (NIMH) in 1954, he began numerous experiments with rats and mice. During his first tests, he placed around 32 to 56 rats in a 10-by-14-foot (3.0 m × 4.3 m) cage in a barn in Montgomery County. He separated the space into four rooms.
For reasons of reproducibility, genetically characterized, stable strains like C57BL/6 were chosen to produce high-resolution images and databases. [1] Well known online resources include: Allen Brain Atlas [2] Mouse Brain Library [3] High resolution mouse brain atlas; BrainMaps. High-Resolution Brain Maps and Brain Atlases of Mus musculus
Pacific jumping mice prefer living in moist regions, such as marshes with alder, salmonberry, skunk-cabbage, and riparian alder ecosystems commonly found in coastal redwood woodlands. [4] In northern regions they dwell in dense woodlands, wet grassy regions, and alpine meadows of the Cascade Mountains in Washington and the Olympic Peninsula .