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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
[6] [2] [4] Existing resistant strains of mice, such as C57BL/6, C57BL/10 and AKR, may not have clinical signs that viruses can cause for other animals. [7] It is important to note that the genetic background of the mouse can affect the infection, which means that host factors are involved in the regulation of susceptibility and resistance to ...
C57BL/6 was created by Clarence Little, the first director and founder of JAX. However, he created the strain in 1921 (see here on the JAX site), whereas the Jackson Labs didn't come into being until 1929. In addition, JAX may be the largest supplier of C57BL/6J, but it probably is not the largest supplier of some other substrains, such as ...
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
Charles River Laboratories From a longer title : This is a redirect from a title that is a complete, more complete or longer version of the topic's name. It leads to the title in accordance with the naming conventions for common names and can help writing and searches.
The chickens also exhibited defects in small intestine growth and health. [6] Germ-free mice have been shown to have defects in their immune system and energy uptake due to lacking a healthy microbiome. [3] [4] There is also strong evidence for interactions between the mouse microbiome and its brain development and health.
Individual rats would rarely eat except in the company of other rats. As a result extreme population densities developed in the pen adopted for eating, leaving the others with sparse populations. In the experiments in which the behavioral sink developed, infant mortality ran as high as 96 percent among the most disoriented groups in the population.