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The most common side effects of bicalutamide monotherapy in men are breast pain/tenderness and gynecomastia. [11] These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30]
CPA can sometimes cause breast changes in men including gynecomastia (breast development) and breast tenderness. [10] Rates of gynecomastia of 4 to 30% have been reported. [ 14 ] [ 15 ] [ 16 ] [ 9 ] [ 17 ] Galactorrhea (milk outflow) can also occur in men, due to the strong progestogenic effects of CPA.
Men make up about 1% of all breast cancer cases, which means 1 in 726 men will be diagnosed in their lifetimes. The diagnosis is rare in men, but that is still a lot of men getting breast cancer.
If the condition does not resolve within 2 years, or if it causes embarrassment, pain or tenderness, treatment is warranted. [11] [12] Medical treatment of gynecomastia that has persisted beyond two years is often ineffective. Gynecomastia is different from "pseudogynecomastia", [5] [6] which is commonly present in men with obesity. [13] [14]
“Breast tenderness can increase the week before and during your menstrual cycle,” says Sepulveda. “For patients that have discomfort during their mammogram, we recommend that they come for ...
According to Ruth Oratz, M.D., breast medical oncologist at NYU Langone Health’s Perlmutter Cancer Center, other rare breast-related causes for pain include: Benign cyst Changes resulted to ...
Breast pain is the symptom of discomfort in either one or both breasts. [2] Pain in both breasts is often described as breast tenderness, is usually associated with the menstrual period and is not serious. [1] [3] Pain that involves only one part of a breast is more concerning, [1] particularly if a hard mass or nipple discharge is also present ...
As with breast enlargement caused by spironolactone in women, gynecomastia due to spironolactone in men is often although inconsistently accompanied by breast tenderness. [110] In the RALES, only 1.7% of men developed breast pain, relative to 0.1% of controls. [133]
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