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  2. Discovery and development of NS5A inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    HCV is a positive-sense single-stranded RNA virus that has been demonstrated to replicate in the hepatocytes of both humans and chimpanzees. A single HCV polyprotein is translated, and then cleaved by cellular and viral proteases into three structural proteins (core, E1, and E2) and seven nonstructural proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B).

  3. Protease inhibitor (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Protease_inhibitor...

    The first protease inhibitor approved by the U.S. Food and Drug Administration (FDA). Ritonavir: Norvir: AbbVie: U.S. patent 5,541,206: March 1, 1996: AbbVie was part of Abbott Laboratories when patent was granted. As well as being a protease inhibitor in its own right, ritonavir inhibits the breakdown of other protease inhibitors.

  4. Hepatitis C virus nonstructural protein 5A - Wikipedia

    en.wikipedia.org/wiki/Hepatitis_C_virus...

    It is also possible that NS5A is a critical component during HCV replication and subcellular localization, which may shed light on the poorly understood HCV life cycle. [ 1 ] [ 4 ] Additionally, NS5A has been shown to modulate the polymerase activity of NS5B , an RNA-dependent RNA polymerase (RdRp) . [ 3 ]

  5. Hepatitis C virus nonstructural protein 5B - Wikipedia

    en.wikipedia.org/wiki/Hepatitis_C_virus...

    HCV genome. Nonstructural protein 5B (NS5B) is a viral protein found in the hepatitis C virus (HCV). [1] It is an RNA-dependent RNA polymerase, having the key function of replicating HCV's viral RNA by using the viral positive RNA strand as a template to catalyze the polymerization of ribonucleoside triphosphates (rNTP) during RNA replication.

  6. NS5B inhibitor - Wikipedia

    en.wikipedia.org/wiki/NS5B_inhibitor

    The virus is internalized and the nucleocapsid is released into the cytoplasm of the hepatocyte after binding with the receptor. The NS5B protein, which is an RNA-dependent RNA polymerase, catalyzes hepatitis C virus replication. [10] The hepatitis C virus can cause acute infection but most patients are asymptomatic upon exposure.

  7. List of antineoplastic agents - Wikipedia

    en.wikipedia.org/wiki/List_of_antineoplastic_agents

    Ribonucleotide reductase and DNA polymerase inhibitor. [11] Acute lymphoblastic leukaemia and acute myeloid leukaemia: Myelosuppression, hypokalaemia, cytokine release syndrome, Stevens–Johnson syndrome (uncommon), toxic epidermal necrolysis (uncommon) and pancreatitis (uncommon) Cytarabine: SC, IM, IV, IT: DNA polymerase inhibitor, S-phase ...

  8. The 10 best and 10 worst fruits for you - AOL

    www.aol.com/lifestyle/food-10-best-and-10-worst...

    Experts agree that a diet rich in fruits and veggies is the way to go. Fruits can provide essential nutrients, fiber and a host of other health benefits. If you enjoy fruits frequently, that's great.

  9. Biomarkers of diabetes - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_diabetes

    Type 2 diabetes is a progressive condition in which the body becomes resistant to the normal effects of insulin and/or gradually loses the capacity to produce enough insulin in the pancreas. [2] Pre-diabetes means that the blood sugar level is higher than normal but not yet high enough to be type 2 diabetes. [3]