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Hypoventilation exists when the ratio of carbon dioxide production to alveolar ventilation increases above normal values – greater than 45mmHg. If pH is also less than 7.35 this is respiratory acidosis .
A normal minute volume while resting is about 5–8 liters per minute in humans. [1] Minute volume generally decreases when at rest, and increases with exercise. For example, during light activities minute volume may be around 12 litres. Riding a bicycle increases minute ventilation by a factor of 2 to 4 depending on the level of exercise involved.
Tidal volume increases by 30–40%, from 0.5 to 0.7 litres, [9] and minute ventilation by 30–40% [9] [10] giving an increase in pulmonary ventilation. This is necessary to meet the increased oxygen requirement of the body, which reaches 50 ml/min, 20 ml of which goes to reproductive tissues.
On the other side Ventilation-perfusion mismatch is the term used when the ventilation and the perfusion of a gas exchanging unit are not matched. The actual values in the lung vary depending on the position within the lung. If taken as a whole, the typical value is approximately 0.8. [4]
The alveolar gas equation is the method for calculating partial pressure of alveolar oxygen (p A O 2). The equation is used in assessing if the lungs are properly transferring oxygen into the blood. The alveolar air equation is not widely used in clinical medicine, probably because of the complicated appearance of its classic forms.
Average values for FEV1 in healthy people depend mainly on sex and age, according to the diagram. Values of between 80% and 120% of the average value are considered normal. [14] Predicted normal values for FEV1 can be calculated and depend on age, sex, height, mass and ethnicity as well as the research study that they are based on.
In healthy lungs where the alveolar dead space is small, Fowler's method accurately measures the anatomic dead space using a single breath nitrogen washout technique. [4] [5] The normal value for dead space volume (in mL) is approximately the lean mass of the body (in pounds), and averages about a third of the resting tidal volume (450-500 mL
TLC: Total lung capacity: the volume in the lungs at maximal inflation, the sum of VC and RV. TV: Tidal volume: that volume of air moved into or out of the lungs in 1 breath (TV indicates a subdivision of the lung; when tidal volume is precisely measured, as in gas exchange calculation, the symbol TV or V T is used.)