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Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease , ulcerative colitis , rheumatoid arthritis , ankylosing spondylitis , psoriasis , psoriatic arthritis , and Behçet's disease . [ 23 ]
Monoclonal antibodies used for autoimmune diseases include infliximab and adalimumab, which are effective in rheumatoid arthritis, Crohn's disease and ulcerative colitis by their ability to bind to and inhibit TNF-α. [22] Basiliximab and daclizumab inhibit IL-2 on activated T cells and thereby help preventing acute rejection of kidney ...
Infliximab (Remicade) A monoclonal antibody to TNF, proinflammatory cytokine Crohn's disease, rheumatoid arthritis, ankylosing spondylitis: Respiratory infection, fever, hypotension. Predisposes to infections (reactivation of latent TB) Rituximab (Rituxan) A monoclonal antibody to CD20 surface immunoglobulin
The incidence of developing these antibodies is highest in patients receiving intermittent therapy with infliximab, and lowest in patient receiving continuous therapy and concomitant immunosuppressive therapy. Some suggest that the presence of these antibodies causes a decrease in efficacy of infliximab and increased risk of infusion reactions.
Merck's rheumatoid arthritis blockbuster Remicade provides a tricky entry in this series about the company's main products, now that Singulair is off-patent. Remicade had net sales of $2.1 billion ...
The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel diseaseBiological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
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