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1,4-Butanediol, also called Butane-1,4-diol (other names include 1,4-B, BD, BDO and 1,4-BD), [5] is a primary alcohol and an organic compound with the formula HOCH 2 CH 2 CH 2 CH 2 OH. . It is a colorless viscous liquid first synthesized in 1890 via acidic hydrolysis of N,N'-dinitro-1,4-butanediamine by Dutch chemist Pieter Johannes Dekkers, who called it "tetramethylene glyco
Hepatic VOD is a dose-limiting toxicity. Symptoms of VOD include weight gain, elevated bilirubin, painful hepatomegaly, and edema. The reason busulfan causes VOD is mostly unknown and can be deadly. [4] Ursodiol may be considered for prophylaxis of veno-occlusive disease. Antiemetics are often administered prior to busulfan to prevent vomiting ...
Physical dependence is a physical condition caused by chronic use of a tolerance-forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms. [4] [5] Physical dependence can develop from low-dose therapeutic use of certain medications such as benzodiazepines, opioids, stimulants, antiepileptics and ...
Anecdotal reports indicate that 1,4-butanediol produces a strong toxic feeling not present with GHB when ingested.[13] These reports also indicate that it may cause damage to the liver as well as to other vital organs.[14] The first report involved ingesting 1,4-butanediol together with 5-Meo-DiPT, a powerful hallucinogen.
2-methylpropane-1,2-diol; 2-methylpropane-1,3-diol; and one unstable geminal diol: 2-methylpropane-1,1-diol (not a glycol), hydrate of 2-methylpropanal (isobutyraldehyde) These three methylpropanediols are structural isomers of butanediols. They are not chiral.
1,4-Butanediol diglycidyl ether (B14DODGE) is an organic chemical in the glycidyl ether family. It is aliphatic and a colorless liquid. It has two epoxide (oxirane) groups per molecule. [1] Its main use is in modifying epoxy resins especially viscosity reduction. [2] It is REACH registered. [3] The IUPAC name is 2-[4-(oxiran-2-ylmethoxy ...
A popular children's toy, Bindeez (also known as Aqua Dots, in the United States), produced by Melbourne company Moose, was banned in Australia in early November 2007 when it was discovered that 1,4-butanediol (1,4-B), which is metabolized into GHB, had been substituted for the non-toxic plasticiser 1,5-pentanediol in the bead manufacturing ...
Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent and slower to take effect but longer-acting than GHB. [22] Metabolic pathway of 1,4-butanediol, GBL and GHB