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The total T4 is less accurate due to the large amount of T4 that is bound. The total T3 is measured in clinical practice since the T3 has decreased amount that is bound as compared to T4. [citation needed] Reference ranges depend on the method of analysis. Results should always be interpreted using the range from the laboratory that performed ...
At the cellular level, T 3 is the body's more active and potent thyroid hormone. [2] T 3 helps deliver oxygen and energy to all of the body's cells, its effects on target tissues being roughly four times more potent than those of T 4. [2] Of the thyroid hormone that is produced, just about 20% is T 3, whereas 80% is produced as T 4.
Thyroid hormone binding ratio (THBR) is a thyroid function test that measures the "uptake" of T3 or T4 tracer by thyroid-binding globulin (TBG) in a given serum sample. This provides an indirect and reciprocal estimate of the available binding sites on TBG within the sample. The results are then reported as a ratio to normal serum.
The therapeutic target range TSH level for patients on treatment ranges between 0.3 and 3.0 μIU/mL. [18] For hypothyroid patients on thyroxine, measurement of TSH alone is generally considered sufficient. An increase in TSH above the normal range indicates under-replacement or poor compliance with therapy.
Thyroid hormones are important for normal development. [28] They increase the growth rate of young people, [29] and cells of the developing brain are a major target for the thyroid hormones T 3 and T 4. Thyroid hormones play a particularly crucial role in brain maturation during fetal development and first few years of postnatal life [28]
The results came from a small study comprising 81 participants who had typical thyrotropin levels, which are used to indicate thyroid function, and who were taking levothyroxine.